International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Dec 28, 2020Pharmacological reviews

Classification, Pharmacology, and Function of Serotonin Receptors

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Abstract

This review details the classification and function of 14 distinct 5-HT receptor subtypes in the human body.

5-HT receptors are involved in various physiological and pathological processes.
The diversity of 5-HT receptor structure and function is significant for therapeutic applications.
Understanding the nomenclature of 5-HT receptors may help in developing targeted treatments.
Therapeutics targeting 5-HT receptors could offer benefits in managing certain conditions.

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5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. SIGNIFICANCE STATEMENT: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.

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International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Abstract

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