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Identification of biomarkers associated with mitophagy in bladder cancer
Biomarkers linked to mitochondrial recycling in bladder cancer
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Abstract
CTSK, MTERF3, SRC, and CSNK2B were identified as -related biomarkers associated with bladder cancer.
- A risk model classified bladder cancer patients into high-risk and low-risk groups, with high-risk patients showing lower survival probabilities.
- The signaling pathways 'chemical carcinogenesis-DNA adducts' and 'cytokine-cytokine receptor interaction' were closely linked to the patient risk groups.
- TP53 mutation frequencies were found to be the highest in both the high-risk and low-risk groups.
- Significant differences in 14 immune cell types, including M2 macrophages, were observed between the two risk groups.
- CTSK showed the strongest correlation with naive B cells, indicating its potential relevance in immune response.
- 135 drugs exhibited varying sensitivity between the high-risk and low-risk groups, highlighting potential therapeutic differences.
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Key numbers
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High-Risk Group Size
Patients classified into high-risk group based on risk model.
< 0.001
Survival Rate Reduction
Significant reduction in survival rate for high-risk group compared to low-risk group.
135
Drug Sensitivity Variation
Number of drugs differing in sensitivity between high-risk and low-risk groups.