CRISPR Gene Editing Research,
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CRISPR clears HIV DNA from mice—and reaches 95% editing efficiency in fish cells
This week brought major breakthroughs in CRISPR gene editing, from potentially curing HIV to making the technology work better across different species and applications.
🎯 Engineered Exosomes Deliver CRISPR to Eliminate HIV in Mice
Researchers developed EMT-Cas12a, an engineered exosome system that targets CD4+ T cells and delivers CRISPR components to cut out HIV DNA from infected cells
The system restored CD4+ T cell counts in HIV-infected humanized mice and showed no detectable off-target effects when tested
Multiple guide RNAs worked better than single ones, and the approach successfully eliminated detectable HIV DNA in laboratory cell lines
Why this matters: Unlike current HIV treatments that suppress the virus, this approach may actually eliminate the hidden viral reservoirs that make HIV impossible to cure with existing therapies.
Also in this issue:
- 🔬 Electroporation Achieves 95% Gene Editing Success in Fish Cells
- 🧪 New RNA System Boosts Plant Gene Editing by 78%
- 💡 CRISPR Detects Cancer Mutations at 0.1% Frequency
- 🌱 Modified DNA Templates Increase Gene Insertion 20-Fold in Mice
- 🦠 Viruses Use Host Enzymes to Block CRISPR Defense
- 📊 Machine Learning Maps Key Networks in CRISPR Proteins
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