Recent progress in triazole-based compounds as antimicrobials and how their structure relates to their activity

Triazole-containing compounds exhibit a range of biological activities, including potent antimicrobial effects.

• Bacterial resistance to antibiotics poses a significant threat to global health.
• Triazoles, as five-membered nitrogen-containing compounds, exist in two isomeric forms: 1,2,3-triazole and 1,2,4-triazole.
• These compounds have demonstrated various biological activities, including antibacterial, antifungal, and anticancer properties.
• Recent advances have led to the development of antibiotic triazole hybrids with strong antimicrobial activities.
• Structure-activity relationship studies may enhance the understanding necessary for developing new triazole antimicrobials.

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