2′-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota Modulation and Involvement of the LPS/TLR4 Signaling

Apr 2, 2026Journal of agricultural and food chemistry

2'-Fucosyllactose may reduce high blood pressure in mice by changing gut bacteria and lowering immune signaling

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Abstract

2'-Fucosyllactose (2'-FL) treatment reduced systolic blood pressure by 16.6% in mice with metabolic hypertension.

2'-FL alleviated dyslipidemia, microglial activation, and neuroinflammation in metabolic hypertension mice.
Treatment with 2'-FL increased beneficial bacteria associated with short-chain fatty acids by 3.9-fold and 19.5-fold.
Fecal microbiota transplantation (FMT) demonstrated that the benefits of 2'-FL could be transferred.
The attenuation of vascular dysfunction linked to 2'-FL was associated with inhibition of the lipopolysaccharide/toll-like receptor 4 signaling pathway.
Antihypertensive and metabolic benefits of 2'-FL were connected to modulation of the gut-brain axis.

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2'-Fucosyllactose (2'-FL) shows promise in ameliorating metabolic disorders. However, the role of 2'-FL in metabolic hypertension (MH) remains unclear. This study aimed to evaluate the effects of 2'-FL on MH and explore its underlying mechanisms. 2'-FL treatment (1000 mg/kg) reduced systolic blood pressure (SBP) by 16.6% and alleviated dyslipidemia, microglial activation, and neuroinflammation in MH mice. 2'-FL markedly increased short-chain fatty acids (SCFAs)-producing beneficial bacteria, e.g.,andby 3.9-fold and 19.5-fold, accompanied by increased fecal acetate and butyrate. Notably, the benefits of 2'-FL for MH were transferable via fecal microbiota transplantation (FMT). Particularly, 2'-FL-mediated attenuation of vascular dysfunction was associated with the inhibition of the lipopolysaccharide/toll-like receptor 4 (LPS/TLR4) signaling, a protective effect that could be transferred via FMT. The antihypertensive and metabolic benefits of 2'-FL in mice were accompanied by gut-brain axis modulation. These findings suggest that 2'-FL represents a promising dietary strategy for preventing hypertension-associated complications. Akkermansia Bifidobacterium

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2′-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota Modulation and Involvement of the LPS/TLR4 Signaling

Abstract

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