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High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice
High omega-3 to omega-6 fat ratio may prevent diet-related metabolism and energy problems in mice by affecting mTORC1
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Abstract
Body weight, atherosclerosis markers, insulin signaling, and liver lipid accumulation were significantly lowered in the High ω-3 group compared to the saturated fatty acids group and Low ω-3 group after 12 weeks.
- High ω-3 polyunsaturated fatty acids (PUFAs) intake may positively influence metabolic syndrome in mice fed a high-fat diet.
- Inhibition of specific cellular pathways associated with nutrient sensing was observed with high ω-3 PUFAs, affecting p-mTOR and raptor expression.
- Enhanced mitochondrial function and metabolic activity in the liver were linked to increased consumption of high ω-3 PUFAs.
- Mitochondrial complex activities were elevated, while fumaric acid levels decreased and oxidative stress was reduced in the High ω-3 group.
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