Progressive Insights into 3D Bioprinting for Corneal Tissue Restoration

3D Bioprinting may enable the precise fabrication of corneal tissues, addressing challenges in replicating its complex architecture.

• The cornea's unique structure, comprising organized collagen fibrils and distinct cellular layers, complicates traditional tissue engineering efforts.
• Key biomechanical, optical, and structural properties are crucial for effective corneal engineering and successful 3D bioprinting.
• Current 3D bioprinting methods for corneal tissue engineering are reviewed, along with insights for potential enhancements.
• A suitable corneal bioink must meet specific functional requirements to support effective 3D bioprinting.
• Challenges in replicating the cornea's architecture and function through bioprinting are identified, alongside proposed solutions.
• Innovative techniques like induced pluripotent stem cells and gene therapy may advance corneal regeneration efforts.

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