Journal of psychoactive drugsMar 10, 2020

Use of Methods to Improve Effects Among 5-MeO-DMT Users and Their Links to Mystical, Difficult, and Lasting Experiences

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 10, 2026

Abstract

In a survey of 515 5-MeO-DMT users, benefit enhancement (BE) strategies were reported to be common.

The average age of participants was 35.4 years, with a majority being male (79%) and White/Caucasian (86%).
Users reported employing various BE strategies to enhance positive effects and mitigate challenging experiences.
The use of several BE strategies was linked to significantly more intense mystical-type effects.
Enduring beliefs about the personal meaning and spiritual significance of the experience were also associated with BE strategy use.
Some BE strategies were connected to less intense or challenging experiences.
Further investigation is needed to explore the causal relationship between BE strategies and the effects of 5-MeO-DMT.

Simplified

5-Methoxy--Dimethyltryptamine (5-MeO-DMT) is a potent, fast-acting psychedelic. Anecdotal reports from 5-MeO-DMT users suggest that they employ a variety of benefit enhancement (BE) strategies aimed to increase positive effects and decrease any potential challenging effects of the substance, but no empirical study has investigated this claim. We examined the prevalence of BE strategy use using secondary data from a survey of 5-MeO-DMT users (n = 515; M = 35.4, SD = 11.7; Male = 79%; White/Caucasian = 86%). Results indicated that BE strategy use was common in this sample. As a secondary aim, we assessed whether the use of BE strategies was associated with acute subjective (i.e., mystical-type, challenging) and persisting effects of 5-MeO-DMT among a subset of respondents who reported using 5-MeO-DMT once in their lifetime (n = 116). Results showed that the use of several BE strategies were associated with significantly more intense mystical-type effects and enduring beliefs about the personal meaning and spiritual significance of their experience, and some BE strategies were associated with less intense or challenging experiences. Data suggests that BE strategies are commonly used, and that the use of BE strategies may be associated with increases in positive mystical-type and enduring effects. The causal influence of BE strategies on acute/persisting effects of 5-MeO-DMT should be examined in longitudinal research. N,N age

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Author Disclosures. Conflict of Interest: None

PubMed

Use of Methods to Improve Effects Among 5-MeO-DMT Users and Their Links to Mystical, Difficult, and Lasting Experiences

Abstract

Full Text

Funding

Competing interests

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