A20 may reduce low-oxygen lung artery high blood pressure by blocking inflammation and muscle cell growth

Adenovirus-mediated overexpression of zinc finger protein A20 significantly attenuated the increased right ventricular systolic pressure (RVSP) and pulmonary vascular remodeling in hypoxia-exposed mice.

• Zinc finger protein A20 is associated with negative regulation of NF-κB activity.
• In chronic hypoxia, the expression of A20 decreases over time in lung tissue.
• Overexpression of A20 reduced indicators of pulmonary hypertension, including RVSP and pulmonary vessel muscularization.
• Inhibition of A20 negated the protective effects against inflammation and cell proliferation in pulmonary arterial smooth muscle cells.
• The results suggest that A20 may block the NF-κB signaling pathway linked to hypoxia-induced pulmonary arterial pressure elevation.

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