Accelerated aging in bipolar disorders: An exploratory study of six epigenetic clocks

Significant correlations between chronological age and epigenetic age were observed using six different epigenetic clocks in individuals with bipolar disorder.

• Accelerated epigenetic aging in individuals with bipolar disorder was assessed using various DNA methylation-based markers.
• Body mass index was significantly associated with age accelerations estimated by the six epigenetic clocks.
• GrimAge AgeAccel showed significant associations with male sex, smoking status, and childhood maltreatment.
• DNAm-based telomere length clock AgeAccel was significantly associated with smoking status.
• Distinct epigenetic clocks appear sensitive to different aspects of the aging process in bipolar disorder.

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