Accelerated biological aging is associated with faster multimorbidity progression: a UK biobank study

Each 1-year increase in KDM-BA acceleration is associated with a 9.9% increased risk of multimorbidity progression.

• KDM-BA acceleration and PhenoAge acceleration are defined as biological age accelerations compared to chronological age.
• A 1-year increase in PhenoAge acceleration is associated with a 4.3% increased risk of multimorbidity progression.
• The analysis utilized UK Biobank data from 317,835 participants with a median follow-up of 13 years.
• Cox regression models adjusted for various factors demonstrated consistent results across subgroup and sensitivity analyses.
• PhenoAge acceleration showed the highest predictive performance for multimorbidity progression compared to KDM-BA acceleration and chronological age.

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