Annals of neurology

Faster Biological Aging in Frontotemporal Dementia Linked to Smoking, Inflammation, and Metabolism

Updated

Abstract

The GrimAge2 epigenetic clock was used to investigate biological aging in frontotemporal dementia.

  • Epigenetic clocks serve as biomarkers that reflect biological aging and can be influenced by lifestyle choices and systemic factors.
  • Accelerated biological aging has been linked to neurodegenerative diseases, raising questions about its role in frontotemporal dementia.
  • The study examined the specific impact of smoking-related DNA methylation on biological aging in individuals with frontotemporal dementia.

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