Aging cellAug 26, 2026

Links Between Sleep Patterns Measured by Movement Sensors, Protein Changes, and Aging Signs in Adults

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 27, 2026

Abstract

Longer total sleep duration, greater deep sleep, and increased REM sleep were associated with lower risk of most aging hallmarks.

Higher wakefulness after sleep onset and greater sleep irregularity were linked to higher risk of aging hallmarks.
Light sleep did not show significant associations with aging hallmarks.
The number of proteins associated with both sleep patterns and aging hallmarks varied from 1 to 558.
Identified proteins were mainly involved in immune and inflammatory pathways.
Proteins such as IL1RN, FABP1, GDF15, and LEP were consistently observed across different sleep patterns and aging hallmarks.

Simplified

The associations between objectively measured sleep patterns, the hallmarks of aging, and their shared proteomic signatures remain poorly understood. In this study, we utilized wrist-worn accelerometer data, plasma proteomic profiles, and health records from the UK Biobank to examine the associations between six defined sleep patterns and nine established hallmarks of aging. We further identified proteins jointly associated with both sleep patterns and aging hallmarks. Longer total sleep duration, greater deep sleep, and increased rapid eye movement (REM) sleep were associated with lower risk of most aging hallmarks. In contrast, higher wakefulness after sleep onset (WASO) and greater sleep irregularity were associated with higher risk, whereas light sleep showed no significant associations. The number of overlapping proteins varied substantially across sleep-hallmark associations, ranging from 1 to 558. These proteins were predominantly enriched in immune and inflammatory pathways. Several proteins, including IL1RN, FABP1, GDF15, and LEP, were consistently observed across multiple sleep patterns and aging hallmarks. These findings may help generate hypotheses about shared underlying biological processes between sleep and the aging process.

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Links Between Sleep Patterns Measured by Movement Sensors, Protein Changes, and Aging Signs in Adults

Abstract

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