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Abstract
Cellular senescence may regulate sensitivity to ferroptosis through acid ceramidase activity.
- Cellular senescence is linked to irreversible cell cycle arrest and a specific secretory profile.
- Ferroptosis involves iron-dependent cell death due to lipid peroxidation in cell membranes.
- Acid ceramidase (ACase) plays a role in how senescent cells respond to lipid peroxidation and ferroptosis.
- Changes in the composition of membrane fatty acids are influenced by ACase activity in senescent cells.
- Senescent cells can sensitize nearby non-senescent cells to ferroptosis through a paracrine mechanism.
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