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Acrolein-induced atherosclerosis via AMPK/SIRT1-CLOCK/BMAL1 pathway and the protection from intermittent fasting
How Acrolein May Cause Artery Damage Through a Cellular Energy and Body Clock Pathway and How Intermittent Fasting Might Protect Against It
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Abstract
Intermittent fasting (IF) decreased acrolein-accelerated aortic lesion formation in mice.
- Acrolein exposure at 3 mg/kg/day worsened atherosclerosis by disrupting circadian rhythm.
- IF for 18 hours improved liver and heart tissue responses to acrolein, showing altered gene expression.
- Increased levels of AMPK, phosphorylated AMPK, and SIRT1 were observed with IF treatment.
- Acrolein treatment reduced expression of circadian clock genes, which were restored by IF.
- Short-term fasting also alleviated disruptions in CLOCK/BMAL1 and regulated AMPK and oxidative stress pathways.
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