Toward actionable interventions in human aging (12th ARDD meeting, 2025)

Apr 7, 2026Aging

Developing practical ways to address human aging (12th ARDD meeting, 2025)

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Abstract

The 12th Aging Research and Drug Discovery meeting featured discussions on advancements in aging biology and therapeutic interventions.

The field is moving from descriptive studies to a more mechanistic understanding of aging.
Integration of biological insights with artificial intelligence and machine learning may accelerate drug development.
Novel preclinical research models are being developed to enhance the translation of findings to human trials.
Scientific focus is shifting from cataloging aging hallmarks to identifying and modulating specific molecular mechanisms.
Aging may be a modifiable and potentially reversible biological process rather than just damage accumulation.

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The 12th Aging Research and Drug Discovery (ARDD) meeting convened at the University of Copenhagen, presenting a comprehensive overview of recent advancements in the biology of aging. A central theme across sessions was the field's gradual shift from descriptive, correlational studies to mechanistic understandings enabling the engineering of personalized therapeutic interventions aimed at extending human healthspan. Key discussions highlighted the convergence of multiple disciplines. Presentations detailed how fundamental biological insights are being integrated with artificial intelligence and machine learning platforms for accelerated target identification and drug development. Furthermore, the development and application of novel preclinical research models were presented as critical for improving the translational pipeline to human clinical trials. Scientific discourse has advanced from cataloging the established hallmarks of aging to identifying and modulating the specific molecular mechanisms that regulate them. This focus is predicated on the hypothesis that aging is not solely a result of stochastic damage accumulation but may be a tractable, modifiable, and potentially reversible biological process amenable to intervention. This report summarizes the principal research directions and conceptual frameworks presented at the conference.

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Toward actionable interventions in human aging (12th ARDD meeting, 2025)

Abstract

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