Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascular coagulation in patients admitted to a surgical intensive care unit.

28.7% of patients demonstrated a biphasic waveform during their intensive care unit stay, indicating a potential diagnostic marker for sepsis.

• The biphasic waveform was detected in 16.3% of patients at admission and increased to 28.7% during the entire intensive care unit treatment.
• Among patients with a biphasic waveform on admission, 59.3% were diagnosed with sepsis.
• The sensitivity of aPTT waveform analysis for detecting sepsis ranged from 22% to 55% at admission and 48% to 74% during the total intensive care unit stay.
• Specificity for sepsis detection varied between 92% and 98% at admission and 81% to 94% during the intensive care unit course.
• Biphasic waveform analysis showed comparable specificity for diagnosing overt disseminated intravascular coagulation, but with lower sensitivity.

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