Acupuncture at Different Points May Affect Sleep and Daily Rhythm Genes in the Brain of Insomnia Rats
Updated
Abstract
Manual acupuncture stimulation of GV 20-HT 7 improved sleep duration in insomnia rats compared to other acupoint groups.
- Sleep latency was significantly prolonged and sleep duration considerably shortened in the insomnia model group.
- After treatment, sleep latency decreased significantly in all treatment groups, but only the GV 20-HT 7 group showed a significant increase in sleep duration compared to the insomnia model group.
- No significant differences in sleep latency were observed among the three treatment groups.
- The expression levels of mRNA and Bmal 1 mRNA in the hypothalamic regions were significantly down-regulated in the insomnia model compared to normal controls.
- Treatment with GV 20-HT 7 and GV 20-SP 6 increased mRNA expression in the VLPO and SCN regions compared to the insomnia model group.
- GV 20-HT 7 was more effective than GV 20-SP 6 and GV 20-non-acupoint in up-regulating mRNA and Bmal 1 mRNA expression.
Simplified