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Acute but not chronic activation of brain glucagon‐like peptide‐1 receptors enhances glucose‐stimulated insulin secretion in mice
Short-term activation of brain receptors improves insulin release after glucose in mice, but long-term activation does not
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Abstract
Acute infusion of GLP-1 into the brain potentiates glucose-stimulated insulin secretion and improves glucose tolerance.
- Acute brain GLP-1 infusion enhances insulin secretion in response to glucose.
- Blocking brain GLP-1 receptors impairs glucose handling after a glucose load.
- Sustained activation of brain GLP-1 receptors does not affect insulin secretion or glucose tolerance.
- In high-fat diet mice, acute GLP-1 infusion improves glucose tolerance without altering insulin secretion.
- Chronic activation of brain GLP-1 receptors does not influence glucose homeostasis.
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