Acute Impact of Immediate Release Methylphenidate Administered Three Times a Day on Sleep in Children with Attention-Deficit/Hyperactivity Disorder

Dec 7, 2007Journal of pediatric psychology

Short-term effects of three-times-daily methylphenidate on sleep in children with ADHD

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Abstract

Children with ADHD showed statistically and clinically significant changes in sleep time and onset latency when treated with immediate release Ritalin.

Ritalin, administered three times a day, effectively reduced ADHD symptoms.
Total sleep time increased in children receiving medication compared to those not on medication.
Sleep onset latency, or the time taken to fall asleep, decreased in the medication group.
No significant changes in sleep quality were reported based on sleep questionnaires.

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OBJECTIVE: To determine the impact of immediate release Ritalin, given three times a day, on sleep quality and quantity in medication-naïve, newly diagnosed children with attention-deficit/hyperactivity disorder (ADHD).

METHODS: Children (aged 6-12) rigorously diagnosed with ADHD (n = 21) underwent multiple measurement assessments (i.e., actigraphy, sleep diary, and questionnaires) during a 1-week baseline and then during a 3-week blinded randomized medication trial.

RESULTS: Although the medication was effective in reducing ADHD symptoms, analyses of actigraphy and sleep diary data found statistically and clinically significant changes in the children's total sleep time and sleep onset latency in the medication compared to the no medication conditions. No effects on sleep were found based on the sleep questionnaire.

CONCLUSIONS: Physicians and parents are encouraged to closely monitor children's sleep when treating ADHD with stimulant medication.

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Acute Impact of Immediate Release Methylphenidate Administered Three Times a Day on Sleep in Children with Attention-Deficit/Hyperactivity Disorder

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