Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

Sep 3, 2015American journal of physiology. Endocrinology and metabolism

Fat cells as a model for how immune signals control energy use

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Abstract

Obesity is associated with adipose tissue dysfunction that can lead to several metabolic pathologies.

Adipose tissue acts as an active endocrine organ, producing a wide variety of signaling molecules known as adipokines.
Dysfunction in adipose tissue is linked to obesity-related conditions such as type 2 diabetes, dyslipidemia, and hypertension.
Mechanisms contributing to obesity include increased size and number of fat cells, inflammation in adipose tissue, and changes in the secretion of adipokines.
Brown and beige adipose tissues may play a protective role against obesity by dissipating energy and promoting fat clearance.
Understanding the changes in different types of adipose tissue during weight gain may reveal potential drug targets for obesity treatment.

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Adipose tissue constitutes an extremely active endocrine organ with a network of signaling pathways enabling the organism to adapt to a wide range of different metabolic challenges, such as starvation, stress, infection, and short periods of gross energy excess. The functional pleiotropism of adipose tissue relies on its ability to synthesize and release a huge variety of hormones, cytokines, complement and growth factors, extracellular matrix proteins, and vasoactive factors, collectively termed adipokines. Obesity is associated with adipose tissue dysfunction leading to the onset of several pathologies including type 2 diabetes, dyslipidemia, nonalcoholic fatty liver, or hypertension, among others. The mechanisms underlying the development of obesity and its associated comorbidities include the hypertrophy and/or hyperplasia of adipocytes, adipose tissue inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. Recently, the potential role of brown and beige adipose tissue in the protection against obesity has been also recognized. In contrast to white adipocytes, which store energy in the form of fat, brown and beige fat cells display energy-dissipating capacity through the promotion of triacylglycerol clearance, glucose disposal, and generation of heat for thermogenesis. Identification of the morphological and molecular changes in white, beige, and brown adipose tissue during weight gain is of utmost relevance for the identification of pharmacological targets for the treatment of obesity and its associated metabolic diseases.

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Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

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