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Abstract
Adipose tissue dysfunction is closely linked to aging and the development of multiple diseases.
- Adipose tissue serves as both an energy reservoir and an endocrine organ.
- Key characteristics of adipocyte senescence contribute to obesity, type 2 diabetes, and cardiovascular diseases.
- Current intervention strategies for adipocyte senescence include senolytics, senomorphics, caloric restriction, physical exercise, and gene editing.
- Lipid prodrugs may enhance drug delivery to adipose tissue, potentially increasing local drug concentration and reducing systemic toxicity.
- Exploiting the unique lipid metabolism of adipocytes could provide new therapeutic options for addressing metabolic disorders.
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