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Distinct adipose progenitor cells emerging with age drive active adipogenesis
Special fat-making cells that appear with age promote new fat tissue growth
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Abstract
Adipose progenitor cells in middle-aged mice show a significant increase in their ability to form fat cells.
- Middle age triggers extensive fat cell formation from progenitor cells in visceral fat.
- Adipocyte turnover is low in young adults but increases significantly during middle age.
- A new population of committed preadipocytes emerges in middle age, characterized by higher proliferation and fat-forming activity.
- Signaling through the leukemia inhibitory factor receptor is crucial for the fat-forming ability of these age-enriched preadipocytes.
- These findings highlight a key mechanism behind age-related changes in fat tissue, potentially linking to metabolic disorders.
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