Higher Levels of a Key Enzyme in Fat Tissue May Protect Obese Mice from Metabolic Problems Through Tiny Messenger Particles

Mice with adipocyte NAMPT overexpression were protected from diet-induced metabolic dysfunction.

• Diminished adipocyte NAD+ and NAMPT are linked to metabolic dysfunction.
• Overexpression of NAMPT in adipocytes reduced adipose tissue inflammation.
• Glucose intolerance was prevented in mice with adipocyte NAMPT overexpression.
• Extracellular vesicles from these mice enhanced glucose tolerance in obese mice.
• Significant alterations in lipid and metabolite contents were observed in extracellular vesicles from ANOV mice compared to wild-type mice.

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