Effect of adlay (Coix lachryma‐jobiL. var.ma‐yuenStapf.) hull extracts on testosterone release from rat Leydig cells

Dec 25, 2008Phytotherapy research : PTR

How adlay hull extracts affect testosterone release from rat testis hormone-producing cells

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Abstract

Methanol extracts of adlay hull (AHM) decreased testosterone release in rat Leydig cells.

  • AHM inhibits testosterone synthesis through the suppression of specific signaling pathways.
  • The study observed a reduction in the activity of the 17beta-HSD enzyme, which is involved in testosterone production.
  • AHM also reduced the secretion of luteinizing hormone (LH) when rat pituitary cells were stimulated with gonadotropin-releasing hormone (GnRH).
  • The findings suggest that adlay hull may have an impact on endocrine functions related to testosterone levels.

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