Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production

The adrenal gland's internal clock is crucial for maintaining a robust circadian rhythm of glucocorticoid production.

• The adrenal clock is closely connected to the production of glucocorticoids, a type of adrenal steroid.
• Mice with reduced levels of the clock protein BMAL1 in the adrenal gland exhibit disrupted glucocorticoid production.
• Behavioral rhythms are significantly altered in these mice, suggesting the adrenal clock's influence extends beyond hormone production.
• Changes in the expression of the gene Period1, but not Period2, were observed in various peripheral organs of the affected mice.
• The adrenal peripheral clock is linked to the overall synchronization of the mammalian circadian timing system.

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