Adrenergic receptor activation shapes circadian clock gene oscillations in HL-1 cardiomyocyte cell line

Alpha- and beta-adrenergic receptor activation differentially modulates clock gene expression in HL-1 cardiomyocyte cells.

• Circadian rhythms in physiology, biochemistry, and behavior are regulated by clock genes with a 24-hour cycle.
• Cardiovascular functions, including heart rate and blood pressure, are influenced by circadian variations.
• HL-1 cardiomyocyte cells can be synchronized to study the intrinsic cardiomyocyte circadian clock with minimal external timing influences.
• Different activators of adrenergic receptors impact the levels, variation, and timing of clock gene expression in these cells.
• The findings support the use of HL-1 cells as a model for exploring the relationship between adrenergic signaling and circadian rhythms in heart cells.

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