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Severe liver scarring, but not fatty liver disease, is linked to faster biological aging in the population
Updated
Abstract
Participants with advanced fibrosis exhibited a KDM_advance of 4.22 years and a phenoage_advance of 2.61 years.
- Individuals with advanced fibrosis showed significantly greater compared to those without advanced fibrosis.
- Advanced fibrosis was linked to an increase in biological age measured by both the KDM and Phenoage methods.
- No significant biological aging was identified in participants with .
- The findings suggest that advanced fibrosis may be a critical factor in understanding biological aging in chronic liver disease.
Simplified
Key numbers
4.22 years
KDM_advance in group
Mean biological age advancement in participants with .
1.50 years
KDM_advance increase vs. Non-
Difference in KDM_advance between participants with and without .
0.37 years
KDM_advance
Mean biological age advancement in participants with .