Participants with advanced fibrosis exhibited a KDM_advance of 4.22 years and a phenoage_advance of 2.61 years.
Individuals with advanced fibrosis showed significantly greater compared to those without advanced fibrosis.
Advanced fibrosis was linked to an increase in biological age measured by both the KDM and Phenoage methods.
No significant biological aging was identified in participants with .
The findings suggest that advanced fibrosis may be a critical factor in understanding biological aging in chronic liver disease.
Simplified
BACKGROUND: The process of in patients diagnosed with chronic liver disease remains unclear.
AIM: The current study aims to investigate if there is an accelerated biological aging process in participants with advanced fibrosis () and (MASLD).
METHODS: Data from the 2017-2018 NHANES cycle were analyzed. AF was determined based on the values of liver stiffness measurement (LSM) and MASLD was defined according to new consensus nomenclature. Klemera-Doubal method biological age (KDM bioage) and Phenotypic age (Phenoage) were adopted to quantify biological age. Phenoage advancement (Phenoage_advance) and KDM advancement (KDM_advance) were generated as the difference between the calculated biological age and chronological age, and a positive residual was regarded as an indicator of accelerated biological aging.
RESULTS: A total of 3974 participants was enrolled. The weight mean KDM_advance and phenoage_advance in AF group was 4.22 years (95%CI: 2.96-5.49 years) and 2.61 years (95%CI: 1.80-3.41 years), while in MASLD group was 0.37 years (95%CI: -0.28-1.03 years) and 0.04 years (95%CI: -0.64-0.72 years), respectively. Multivariate linear regression analysis showed that participants with AF had older KDM_advance and phenoage_advance compared with those without AF (1.50 years (95%CI: 0.23-2.77 years), P = 0.02; 1.00 years (95%CI: 0.18-1.82 years), P = 0.02; respectively), in models adjusting demographic characteristics, socioeconomic status, lifestyle factors, and comorbidities. No significant association was found between MASLD and KDM_advance and phenoage_advance.
CONCLUSIONS: AF, not MASLD, was independently associated with accelerated biological aging in adults from a US representative sample.
Key numbers
4.22 years
KDM_advance in group
Mean biological age advancement in participants with .
1.50 years
KDM_advance increase vs. Non-
Difference in KDM_advance between participants with and without .
0.37 years
KDM_advance
Mean biological age advancement in participants with .
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Declarations. Ethics and consent to participate: The NHANES is a large-scale nutritional and epidemiological research project conducted by the United States Public Health Service, and the written informed consent was submitted by each participant. The data that support the findings of this study are openly available in NHANES. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
