[Effect of aerobic exercise on the expression of CLK2 protein in liver of mice fed with high fat diet].

Mice fed a high fat diet showed increased hepatic CLK2 protein expression and fat content.

• Insulin resistance was observed in mice on a high fat diet compared to those on a normal diet.
• The hepatic CLK2 content and fat accumulation were higher in the high fat diet group.
• Chronic aerobic exercise improved insulin resistance in the high fat diet group.
• Exercise prevented the increase of CLK2 protein in the liver.
• Aerobic exercise reduced fat accumulation in the liver of mice fed a high fat diet.

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