mTORC1’s role in brain aging, nerve cell damage, and potential treatments

Chronic mTORC1 hyperactivity is associated with mitochondrial dysfunction and neuroinflammation during aging.

• Aging leads to a decline in cellular homeostasis, increasing the risk of neurodegenerative diseases.
• mTORC1 plays a central role in regulating metabolism and integrating nutrient sensing with cellular growth.
• Overactivation of mTORC1, known as mTORopathy, contributes to the accumulation of toxic proteins like amyloid-beta and tau.
• Increased mTORC1 activity suppresses autophagy and glymphatic function, exacerbating neurodegeneration.
• Inhibition of mTORC1 through compounds like rapamycin may restore autophagic processes and reduce inflammation.
• Targeting mTORC1 could have potential therapeutic benefits for improving synaptic function and neurogenesis.

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