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Abstract
Age-related ocular pathologies are contributing to a significant public health challenge as the population ages, notably affecting conditions such as age-related macular degeneration (AMD).
- The molecular mechanisms involved in age-related eye diseases include telomere shortening, oxidative stress, and cellular aging.
- Oxidative stress leads to the accumulation of reactive oxygen species (ROS), which may play a role in ocular degeneration.
- Inflammation linked to cellular aging is driven by a phenomenon known as the senescence-associated secretory phenotype (SASP).
- Dysfunction in the process of cellular cleanup, or autophagy, is associated with the progression of age-related ocular conditions.
- Recent advancements in therapies include gene editing, stem cell approaches, and senolytic agents aimed at mitigating these age-related changes.
- AI-assisted diagnostics could enhance early detection of ocular diseases through improved retinal imaging and biomarker analysis.
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