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The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
How aging, inflammation, and stress in the body’s daily clock relate to brain decline
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Abstract
Circadian clock disruption may influence aging processes and the onset of neurodegenerative diseases.
- The circadian clock regulates various biological processes, including metabolism and immune responses.
- Sleep abnormalities are common in aging and neurodegeneration, indicating a link to circadian disruption.
- There is a bidirectional relationship between aging and the circadian system.
- Age-related deterioration of circadian rhythms could worsen multiple pathogenic processes in the brain.
- The specific mechanisms connecting circadian systems, aging, and the immune system remain under investigation.
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