Agmatine may boost cell cleaning processes to reduce gut cell death caused by sepsis

The role of polyamine supplements in sepsis-induced intestinal injury is uncertain.

• Agmatine (AGM) is being investigated for its potential protective effects against intestinal injury caused by sepsis.
• Sepsis is associated with multiple organ dysfunction and increased mortality.
• The study focuses on understanding how AGM may influence cell survival in intestinal epithelial cells (IECs).
• A mitochondrial-targeted antiapoptotic mechanism is being explored as a possible action of AGM.

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