Biochemical pharmacology

Interaction between the AHR signaling pathway and the body’s daily biological clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

AHR expression levels show diurnal variation in many tissues.

  • Circadian rhythm influences various physiological functions, including behavior and metabolism.
  • BMAL1 is identified as a crucial regulator in the transcriptional feedback loop governing circadian rhythms.
  • The structural similarity between BMAL1 and ARNT suggests a potential link between AHR signaling and circadian regulation.
  • Pharmacological effects of AHR agonists may vary depending on the time of administration due to circadian variation.
  • AHR agonists can disrupt circadian rhythms, affecting behavior and immune cell proliferation.

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