Air, Noise, and Light Pollution and Thromboembolic Cardiovascular Complications: A TH Scientific Statement

Mar 13, 2026Thrombosis and haemostasis

Air, Noise, and Light Pollution Linked to Blood Clots and Heart Problems

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Abstract

Air pollution is the most significant environmental determinant of cardiovascular health globally.

Thromboembolic cardiovascular diseases contribute significantly to global morbidity and mortality.
Exposure to various pollutants, including particulate matter and noise, may promote mechanisms that lead to cardiovascular issues.
Environmental factors like urbanization and industrialization are associated with worsening cardiovascular health outcomes.
The combined effects of different pollutants on vascular health are not fully understood.
There is a need for multidisciplinary research and effective prevention policies to address the cardiovascular impacts of environmental pollution.

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Thromboembolic cardiovascular diseases (CVD), including acute coronary syndromes, ischemic stroke, and venous thromboembolism, remain a leading cause of morbidity and mortality worldwide. Despite significant improvements in prevention and diagnosis, thromboembolic CVD remains a major global health challenge, reflecting the incomplete control of multifactorial vascular risk. Growing evidence indicates that air, noise, and light pollution are important yet underrecognized contributors to cardiovascular morbidity. Exposure to particulate matter (PM, PM), gaseous pollutants (NO, SO, CO, O), chronic noise, and artificial light at night promotes endothelial dysfunction, oxidative stress, inflammation, and platelet activation-key mechanisms fostering a prothrombotic setting. Although regulatory progress has been achieved, air pollution remains the most significant environmental determinant of cardiovascular health globally, and the combined effects of coexisting pollutants are not fully understood. The convergence of urbanization, industrialization, and increasing light exposure further amplifies environmental impacts on vascular health. This scientific statement aims to synthesize current epidemiological and mechanistic evidence, highlight the complex interactions among air, noise, and light pollution, identify critical research gaps, and provide a comprehensive conceptual framework for understanding how environmental stress contributes to thromboembolic cardiovascular complications. Strengthening multidisciplinary research, integrating exposome-based data, and implementing effective prevention policies are essential steps toward mitigating the cardiovascular burden of environmental pollution. 2.5 10 2 2 3

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Air, Noise, and Light Pollution and Thromboembolic Cardiovascular Complications: A TH Scientific Statement

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