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Akkermansia muciniphila: A double-edged sword in life-stage-specific nutritional modulation of Parkinson’s disease via the gut-brain axis
Akkermansia muciniphila's mixed role in how nutrition affects Parkinson's disease at different life stages through the gut-brain connection
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Abstract
Akkermansia muciniphila (A. muciniphila) shows both positive and negative correlations with motor and non-motor symptoms in Parkinson's disease (PD) across different subtypes.
- A. muciniphila's abundance varies throughout the lifespan, peaking in adulthood and declining with age, but resurgent in longer-lived individuals.
- Distinct associations with PD phenotypes suggest a complex role for A. muciniphila in disease progression.
- Dietary and host factors influence the levels of A. muciniphila from gestation to old age.
- A lifespan-targeted intervention model is proposed to modulate A. muciniphila for potential benefits in PD and healthy aging.
- Strategies may include suppressing neurotoxic pathways in at-risk individuals while promoting beneficial functions in aging.
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