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Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an α-synuclein rat model of Parkinson’s disease
Changes in daily activity patterns and internal clock problems in a rat model of Parkinson's disease
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Abstract
Behavioral testing revealed robust phase-dependent modulation of exploratory activity and other behaviors in wild-type rats, which was absent in α-synuclein-overexpressing rats.
- α-synuclein-overexpressing rats showed no phase-dependent modulation in exploratory activity, locomotion, sucrose preference, and olfaction-guided feeding.
- Histological analyses indicated reduced cell density and increased α-synuclein accumulation in the suprachiasmatic nucleus of α-synuclein rats.
- Altered cellular composition was observed in the suprachiasmatic nucleus, including changes in neuronal, orexinergic, and microglial markers.
- A positive correlation was found between α-synuclein load and the counts of Orexin A fibers and Iba1 cells, suggesting a link to neuroinflammation.
- These findings indicate that α-synuclein rats exhibit early suprachiasmatic nucleus pathology and a lack of phase-dependent behavioral changes.
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