Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario

Aug 7, 2019Environment international

Air Pollution Exposure and New Cases of Heart Failure and Heart Attacks in 5.1 Million Adults in Ontario

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

From 2001 to 2015, there were 422,625 incident cases of congestive heart failure (CHF) and 197,628 cases of acute myocardial infarction (AMI) among long-term residents in Ontario, Canada.

Long-term exposure to fine particulate matter (PM), nitrogen dioxide (NO), and ozone (O) is associated with increased incidence of CHF and AMI.
For each interquartile range increase in PM exposure, the hazard ratio for CHF is 1.05, indicating a 5% increase in risk.
The hazard ratios for CHF related to NO and O are 1.02 and 1.03, suggesting a smaller increase in risk for these pollutants.
The concentration-response relationships differ among pollutants, with PM showing a supralinear relationship with CHF and a linear relationship with AMI.

AI simplified

Long-term exposure to ambient air pollution has been linked to cardiovascular mortality, but the associations with incidence of major cardiovascular diseases are not fully understood, especially at low concentrations. We aimed to investigate the associations between exposure to fine particulate matter (PM), nitrogen dioxide (NO), ozone (O), redox-weighted average of NOand O(O) and incidence of congestive heart failure (CHF) and acute myocardial infarction (AMI). Our study population included all long-term residents aged 35-85 years who lived in Ontario, Canada, from 2001 to 2015 (~5.1 million). Incidence of CHF and AMI were ascertained from validated registries. We assigned estimates of annual concentrations of pollutants to the residential postal codes of subjects for each year during follow-up. We estimated hazard ratios (HRs) and 95% CIs for each pollutant separately using Cox proportional hazards models. We examined the shape of concentration-response associations using shape-constrained health impact functions. From 2001 to 2015, there were 422,625 and 197,628 incident cases of CHF and AMI, respectively. In the fully adjusted analyses, the HRs of CHF corresponding to each interquartile range increase in exposure were 1.05 (95% CI: 1.04-1.05) for PM, 1.02 (95% CI: 1.01-1.04) for NO, 1.03 (95% CI: 1.02-1.03) for O, and 1.02 (95% CI: 1.02-1.03) for Orespectively. Similarly, exposure to PM, O, and Owere positively associated with AMI. The concentration-response relationships were different for individual pollutant and outcome combinations (e.g., for PMthe relationship was supralinear with CHF, and linear with AMI). 2.5 2 3 2 3x2.5 2 3x, 2.5 3x2.5

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief