Activation of the AMPK/USP10 cycle increases ACE2 and its possible link to lung high blood pressure

The study investigates the role of USP10 in the pulmonary endothelium's response to pulmonary arterial hypertension (PAH).

• The balance between ACE1 and ACE2 is crucial for understanding PAH.
• USP10 is associated with processes like tumour suppression and cell proliferation.
• A potential feedback loop involving USP10 and AMPK may influence the pulmonary endothelium's protective mechanisms against PAH.

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