Amygdala functional disconnection with the prefrontal-cingulate-temporal circuit in chronic tinnitus patients with depressive mood

Jul 10, 2017Progress in neuro-psychopharmacology & biological psychiatry

Reduced communication between the emotion system and thinking-control areas in chronic tinnitus patients with depression

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Abstract

Chronic tinnitus patients with depressive mood (n=20) showed decreased amygdala functional connectivity with the prefrontal and anterior cingulate cortices.

Depressive tinnitus patients had increased amygdala connectivity with the postcentral and lingual gyri compared to non-depressed tinnitus patients.
Relative to healthy controls, depressive tinnitus patients exhibited decreased amygdala connectivity with the superior and middle temporal gyri, as well as both the anterior and posterior cingulate cortices.
This study identified abnormal resting-state amygdala-cortical functional connectivity in chronic tinnitus patients with depressive mood, suggesting altered neural circuits.

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Chronic tinnitus is often accompanied with depressive symptom, which may arise from aberrant functional coupling between the amygdala and cerebral cortex. To explore this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to investigate the disrupted amygdala-cortical functional connectivity (FC) in chronic tinnitus patients with depressive mood. Chronic tinnitus patients with depressive mood (n=20), without depressive mood (n=20), and well-matched healthy controls (n=23) underwent resting-state fMRI scanning. Amygdala-cortical FC was characterized using a seed-based whole-brain correlation method. The bilateral amygdala FC was compared among the three groups. Compared to non-depressed patients, depressive tinnitus patients showed decreased amygdala FC with the prefrontal cortex and anterior cingulate cortex as well as increased amygdala FC with the postcentral gyrus and lingual gyrus. Relative to healthy controls, depressive tinnitus patients revealed decreased amygdala FC with the superior and middle temporal gyrus, anterior and posterior cingulate cortex, and prefrontal cortex, as well as increased amygdala FC with the postcentral gyrus and lingual gyrus. The current study identified for the first time abnormal resting-state amygdala-cortical FC with the prefrontal-cingulate-temporal circuit in chronic tinnitus patients with depressive mood, which will provide novel insight into the underlying neuropathological mechanisms of tinnitus-induced depressive disorder.

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Amygdala functional disconnection with the prefrontal-cingulate-temporal circuit in chronic tinnitus patients with depressive mood

Abstract

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