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Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross‐sectional associations with early cognitive impairments
Overlap of amyloid and tau brain changes in Down syndrome and early Alzheimer's linked to early thinking problems
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Abstract
For a given (Aβ) burden, individuals with (DS) exhibited greater burden than neurotypical aging.
- Cognitively stable DS individuals show higher tau levels compared to neurotypical individuals at similar Aβ levels.
- DS individuals with mild cognitive impairment or Alzheimer's disease display more widespread tau pathology.
- Aβ-associated tau burden is linked to episodic memory impairment in DS before dementia onset.
- Executive dysfunction becomes evident as Alzheimer's disease progresses in individuals with DS.
- Early striatal Aβ accumulation in DS may serve as a potential biomarker for monitoring disease progression.
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Key numbers
27%
Higher Burden
Approximately 27% of individuals exhibited positive subject scores.
0.50
Cognitive Impairment Correlation
Higher expressions of the Aβ pattern were correlated significantly with age.