Anemia, inflammation, circadian rhythm and season effects in febrile convulsions

No SJR dataJan 23, 2026Northern clinics of Istanbul

How Anemia, Inflammation, Body Clock, and Season Relate to Fever-Related Seizures

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

The average age of children with febrile convulsions was 25.7 months.

Circadian rhythm and seasonal application were similar for both children with febrile convulsions and healthy controls.
The male-to-female ratio among patients was 1.3.
Mean platelet volume (MPV) was significantly lower in winter compared to other seasons.
Younger patients had higher lymphocyte counts and lower neutrophil-to-lymphocyte ratios (NLR).
NLR was lower in patients with febrile convulsions who also had anemia compared to those without anemia.
One third of the patients exhibited hypocapnia, indicating potential respiratory involvement.

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OBJECTIVE: Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions.

METHODS: The data of a total of 478 children, consisting of 160 patients with febrile convulsions (90 male/70 female) and 318 control groups (healthy, convulsiyon free- febrile), were compared.

RESULTS: The average age of all patients was 25.7±14.7 (minimum 6-maximum 60) months, and the most common convulsion age was 13-18 months. Circadian rhythm was similar, application seasons were similar. The male/female ratio was 1.3. MPV in winter was lower than other seasons (p=0.002). At younger ages, lymphocyte count was higher (p=0.048) and NLR was lower (p=0.036). NLR was lower in patients with febrile convulsions with anemia than in patients with febrile convulsions without anemia (p=0.029). NLR was lower in patients with febrile convulsions with anemia than in the convulsion-free febrile control group with anemia (p=0.001). In patients with febrile convulsions, MPV was lower (p=0.033) and NLR was higher (p=0.001) than in the convulsion-free febrile control group. One third of the patients had hypocapnia.

CONCLUSION: Young age, anemia, inflammation, and hypocapnia may facilitate the occurrence of febrile convulsions. MPV and NLO, which are hemogram parameters, can guide us about inflammation. Blood gases may provide information regarding hypocapnia. These rapid examinations may help elucidate the etiology. Prospective studies are needed for circadian rhythm in febrile convulsions.

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