How Angelica Pubescens-Taxillus Chinensis compounds may help relieve spine disc damage caused by pressure through the piezo1/NF-κB signaling pathway

Abnormal mechanical load is a critical risk factor for intervertebral disc degeneration (IVDD).

• Nucleus pulposus (NP) cell senescence is a key mechanism associated with IVDD.
• Piezo1, a mechanosensitive ion channel, may play a role in the response to mechanical stress.
• The NF-κB pathway is linked to the promotion of cellular senescence.
• Duhuo Jisheng decoction, a classical herbal formula, may offer potential benefits for IVDD-related conditions.
• The herb pair Angelica Pubescens-Taxillus Chinensis is considered critical for the therapeutic effects of Duhuo Jisheng decoction.

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