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Abstract
Essence
Repurposed drugs may target aging biology, but clinical translation remains uncertain.
Evidence
This review synthesizes anti-ageing drug research on aspirin, atorvastatin, enalapril, metformin, canagliflozin, liraglutide, acarbose, N-acetylcysteine, and dasatinib with quercetin across mTOR, AMPK, NF-kappa B, and SASP-related pathways, emphasizing healthspan and lifespan signals in model organisms.
Caveat
The abstract highlights major translation barriers, including species specificity, sex differences, unreliable aging biomarkers, and unresolved dose selection.
Simplified
Longevity & Aging