Ageing research reviewsDec 13, 2025

Comparing the anti-aging effects of PQQ and NMN/NR and their possible combined use

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 7, 2026

Abstract

Pyrroloquinoline Quinone (PQQ) and Nicotinamide Mononucleotide/Nicotinamide Riboside (NMN/NR) may provide distinct strategies for promoting healthy aging and longevity.

Aging involves a decline in cellular functions, increasing the risk of chronic diseases.
PQQ enhances the creation of new mitochondria, has antioxidant properties, and influences inflammation.
NMN/NR serve as essential building blocks for nicotinamide adenine dinucleotide (NAD+), important for energy use and DNA repair.
The combination of PQQ and NMN/NR may lead to a synergistic effect, utilizing their complementary mechanisms.
Despite some preliminary data, robust scientific evidence supporting the combined anti-aging effects of PQQ and NMN/NR is still lacking.

Simplified

Aging is a complex biological process characterized by the gradual deterioration of cellular functions, leading to an increased susceptibility to chronic diseases. In the search for interventions to promote healthy aging and extend lifespan, Pyrroloquinoline Quinone (PQQ) and Nicotinamide Mononucleotide/Nicotinamide Riboside (NMN/NR) have emerged as promising anti-aging agents. PQQ exerts its anti-aging effect primarily through enhancing mitochondrial biogenesis, exerting antioxidant activity, and modulating inflammatory pathways. On the other hand, NMN/NR act as key precursors in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in energy metabolism, cellular homeostasis, and DNA repair, thereby promoting longevity. This review systematically compares the mechanisms of action and efficacy of those compounds in mitigating age-related complications. Furthermore, this emphasizes the potent synergistic effect when PQQ and NMN/NR are used in combined formulations, highlighting their complementary pathways to support healthy aging. Despite supporting preliminary data and patented formulations, strong scientific evidence encouraging the synergistic anti-aging potential of PQQ and NMN/NR remains limited, highlighting the need for robust studies. Collectively, PQQ and NMN/NR offer distinct complementary strategies to promote healthy aging and prevent age-related diseases; their combination could offer a more effective approach to enhance healthy aging and longevity.

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Competing interests

Declaration of Competing Interest The authors have declared no conflict of interest.

PubMed

Comparing the anti-aging effects of PQQ and NMN/NR and their possible combined use

Abstract

Full Text

Funding

Competing interests

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