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Anti-aging strategies and ex vivo organ rejuvenation
Methods to Slow Aging and Restore Organs Outside the Body
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Abstract
Partial reprogramming could reverse age-related cellular damage through the transient expression of Yamanaka factors.
- Aging is associated with a decline in physiological function and an increased risk of chronic diseases.
- Interventions targeting the molecular hallmarks of aging include lifestyle changes, drugs, and genetic strategies.
- Partial reprogramming aims to restore youthful cellular characteristics without losing cell identity.
- Ex vivo machine perfusion technology allows rejuvenation therapies to be applied to donor organs outside the body.
- Combining partial reprogramming with organ perfusion may improve organ quality and transplantation outcomes.
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