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Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
How Well Different Weight-Loss Medications Work in Everyday Use
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Abstract
A total of 132 participants, or 64.4%, achieved at least 5% weight loss after 6 months of anti-obesity medication treatment.
- Phentermine was associated with the highest prevalence of achieving ≥5% weight loss compared to other medications, except for liraglutide.
- Specific weight loss rates after 6 months were: 87.2% for phentermine, 67.7% for phentermine/topiramate, 58.1% for liraglutide, 35.3% for naltrexone/bupropion, 75% for lorcaserin, and 50% for orlistat.
- Significant differences in body weight, body mass index, and body fat mass were observed among the different anti-obesity medication groups.
- No significant changes were reported in waist circumference, skeletal muscle mass, percentage body fat, or visceral fat area across the groups.
- The findings suggest that various can effectively induce weight loss without significant impacts on muscle mass.
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Key numbers
132 of 205
Weight Loss Achievement Rate (≥5%)
Total participants achieving ≥5% weight loss after 6 months
62 of 205
Weight Loss Achievement Rate (≥10%)
Total participants achieving >10% weight loss after 6 months
87.2%
Prevalence of Weight Loss (Phentermine)
Percentage of phentermine users achieving ≥5% weight loss