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Antibody responses to different SARS-CoV-2 variants after KP.2 single-strain mRNA vaccination

Updated

Abstract

Neutralizing antibody responses were assessed in 56 adults following KP.2 vaccination against emerging SARS-CoV-2 variants.

  • KP.2 vaccination enhanced neutralization against the original virus but showed substantial reductions against emerging Omicron variants.
  • Participants with a history of vaccination-only exhibited better cross-neutralization compared to those with hybrid immunity.
  • Antigenic mapping indicated significant differences between KP.2 and emerging variants, suggesting a high potential for immune escape.
  • The data indicate that KP.2 boosting primarily enhances responses to previously encountered spike proteins, with limited effectiveness against drifted variants.

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Funding

Competing interests

Declaration of interests FK declares the following conflicts of interest. The Icahn School of Medicine at Mount Sinai has filed patent applications regarding influenza virus vaccines on which FK is listed as inventor. The Icahn School of Medicine at Mount Sinai has filed patent applications relating to SARS-CoV-2 serological assays, NDV-based SARS-CoV-2 vaccines, influenza virus vaccines and influenza virus therapeutics which list FK as co-inventor. Dr. Simon is also listed on the SARS-CoV-2 serological assays patent. FK has received royalty payments from some of these patents. Mount Sinai has spun out a company, Castlevax, to develop SARS-CoV-2 vaccines. FK is co-founder and scientific advisory board member of Castlevax. FK has consulted for Merck, GSK, Sanofi, Curevac, Gritstone, Seqirus and Pfizer and is currently consulting for 3rd Rock Ventures and Avimex. The Krammer laboratory is also collaborating with Dynavax on influenza vaccine development. The Simon and van Bakel labs collaborate with Sanofi Pasteur on pathogen surveillance.
PubMed

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