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Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma
Methods to improve anticancer drug delivery through the brain’s protective barrier to treat glioblastoma
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Abstract
Effective concentrations of anticancer drugs may not reach the invasive regions of glioblastoma due to the influence of the blood-brain barrier.
- Glioblastoma is a highly aggressive brain tumor that resists standard treatments.
- Molecularly targeted therapies have shown limited success in treating this tumor type.
- The blood-brain barrier can hinder the distribution of drugs to both the tumor core and its invasive regions.
- Strategies to enhance drug delivery to glioblastoma are being explored.
- Identifying factors that restrict drug delivery may improve treatment outcomes.
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