Antidepressant effects of SY-2476, a caffeine-based drug, linked to gene changes in stress-induced depressed rats

Treatment with Sy-2476 significantly increased sucrose preference (p = 0.0002) and reduced immobility time (p = 0.0118) in a rat model of depression.

• Sy-2476 demonstrated robust antidepressant-like effects in corticosterone-exposed rats.
• The treatment reduced lipid peroxidation and increased levels of antioxidant enzymes, such as glutathione, catalase, and superoxide dismutase.
• Sy-2476 significantly lowered cortisol levels (p = 0.0019) compared to the corticosterone-only treated group.
• The compound up-regulated mRNA expression of A1 (p = 0.0001) and A2 receptors (p = 0.0016).

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